Publications

Publications

Works from the Fraenkel lab at MIT

(In Preparation) Leventhal, Matthew, Joseph Benetatos, Camilla A Zanella, Byunguk Kang, Christopher Ng, David Housman, Clemens R Scherzer, Mel B Feany, Ernest Fraenkel. A systems biology approach reveals common pathways of neurodegeneration

Works from the Broad Institute with Benjamin Ebert and Gad Getz in Clonal Hematopoiesis

Ellen Beauchamp, Matthew Leventhal, Elsa Bernard, Emma Hoppe, Gabriele Todisco Maria Creignou, Anna Galli, Cecilia Castelano, Marie McConkey, Akansha Tarun, Waihay Wong, Monica Schenone, Caroline Stanclift, Benjamin Tanenbaum, Edyta Malolepsza, Björn Nilsson, Alexander Bick, Joshua Weinstock, Mendy Miller, Abhishek Niroula, Andrew Dunford, Amaro Taylor-Weiner, Timothy Wood, Alex Barbera, Shankara Anand, Bruce Psaty, Pinkal Desai, Michael Cho, Andrew Johnson, Ruth Loos, Daniel MacArthur, Monkol Lek, Donna Neuberg, Kasper Lage, Steven Carr, Eva Hellström-Lindberg, Luca Malcovati, Elli Papaemmanuil, Chip Stewart, Gad Getz, Robert Bradley, Siddhartha Jaiswal and Benjamin Ebert. 2021. ZBTB33 is Mutated In clonal hematopoiesis and myelodysplastic syndromes and impacts RNA Splicing. Blood Cancer Discovery.

Bick, Alex G, …, Matthew J Leventhal, …, Sekar Kathiresan and Pradeep Natarajan. 2020. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 586: 763-768.

Mouhieddine, Tarek H, Adam S Sperling, Robert Redd, Jihye Park, Matthew Leventhal, Christopher J. Gibson, Salomon Manier, Amin H Nassar, Marzia Capelletti, Daisy Huynh, Mark Bustoros, Romanos Sklavenitis-Pistofidis, Sabrin Tahri, Klavis Hornburg, Henry Dumke, Muhieddine M Itani, Cody J Boehner, Chia-Jen Liu, Saud H AlDubayan, Brendan Reardon, Eliezer M Van Allen, Jonathan J Keats, Chip Stewart, Shaadi Mehr, Daniel Auclair, Robert L Schlossman, Nikhil C Munshi, Kenneth C Anderson, David P Steensma, Jacob P Laubach, Paul G Richardson, Jerome Ritz, Benjamin L Ebert, Robert J Soiffer, Lorenzo Trippa, Gad Getz, Donna S Neuberg and Irene M Ghobrial. 2020. Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant. Nature Communications. 11: 1-9.

Sperling, Adam S, Matthew Leventhal, Christopher J. Gibson, Benjamin L. Ebert, and David Steensma. 2019. Myelodysplastic syndromes (MDS) occurring in Agent Orange exposed individuals carry a mutational spectrum similar to that of de novo MDS. Leukemia and Lymphoma. 61 (3): 728-731.

Boettcher, Steffen, Peter G. Miller, Rohan Sharma, Marie McConkey, Matthew Leventhal, Xiaoping Yang, Federica Piccioni, Jesi Kim, Sherry Chao, Andrei V. Krivtsov, Andrew O. Giacomelli, William C. Hahn, Tyler Jacks, Hartmut Doehner, Scott A. Armstrong, Benjamin L. Ebert. 2019. A dominant-negative effect drives selection of TP53 missense mutations in acute myeloid leukemia. Science. 365 (6453): 599-604.

Jan, Max, Matthew J Leventhal, Elizabeth A Morgan, Jordan C Wengrod, Anewsha Nag, Samantha D Drinian, Bruce M Wollison, Matthew D Ducar, Aaron R Thorner, Natasha Kekre, Vincent T Ho, John Koreth, Corey S Cutler, Sarah Nikiforow, Edwin P Alyea III, Joseph H Antin, Robert J Soiffer, Jerome Ritz, R. Coleman Lindsley, and Benjamin L Ebert. 2019. Recurrent genetic HLA loss in Acute Myeloid Leukemia relapsed after matched unrelated allogeneic hematopoietic cell transplant. Blood Advances. 3 (14): 2199–2204.

Undergraduate work

Douhovnikoff, Vladimir, and Matthew Leventhal. 2016. The use of Hardy Weinberg Equilibrium in clonal plant systems. Ecology and Evolution. http://onlinelibrary.wiley.com/doi/10.1002/ece3.1946/full.

Workshops

Tariq, Ifrah, Matthew Leventhal, Diep Nguyen. Estimating Latent Space Uncertainty to Improve Integration of Multi-Omic Sequencing Data. Learning Meaningful Representations of Life Workshop at the Conference on Neural Information Processing Systems (NeurIPS).

Conference abstracts

Jan, Max, Matt J Leventhal, Elizabeth A Morgan, Jordan C Wengrod, Anewsha Nag, Samantha D Drinian, Bruce M Wollison, Matthew D Ducar, Aaron R Thorner, Natasha Kekre, Vincent T Ho, John Koreth, Corey S Cutler, Sarah Nikiforow, Edwin P Alyea III, Joseph H Antin, Robert J Soiffer, Jerome Ritz, R. Coleman Lindsley, and Benjamin L Ebert. Recurrent genetic HLA loss in Acute Myeloid Leukemia relapsed after matched unrelated allogeneic hematopoietic cell transplant. American Society of Hematology. December 1, 2018. https://ash.confex.com/ash/2018/webprogram/Paper113911.html

Matthew Leventhal. Improving the efficiency of statistical analysis of cancer genomes through the development of cloud-based software. American Mathematical Society Special Session on Undergraduate Research. September 24, 2016. http://www.ams.org/amsmtgs/2238_abstracts/1121-92-218.pdf